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Long-term Tamoxifen Use Increases Risk of Aggressive Breast Cancer September 30, 2009

Posted by feminestra in Breast Cancer, Health.
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In one of my recent post, I said that the drug Tamoxifen, which was approved by the FDA, reduced the risk of breast cancer up to 50%. However, in an article released today, a study found that Tamoxifen may in fact cause some breast cancers.
Long-term Tamoxifen Use Increases Risk of Aggressive Breast Cancer « Web of Evidence: What They Don’t Want You To Know

According to the National Cancer Institute (NCI), side effects of the drug range from hot flashes, vaginal dryness, joint pain and leg cramps to blood clots, cataracts, strokes and uterine cancer. Understandably, many women are willing to accept these risks because they are told tamoxifen decreases their chance for a recurrence of breast cancer. However, a new study by Christopher Li, M.D., Ph.D., and colleagues at Fred Hutchinson Cancer Research Center just published online in the journal Cancer Research seems to reveal the belief that tamoxifen protects against breast cancer is only partially correct. The drug may also cause certain breast cancers.

Yes, breast-cancer patients who receive long-term estrogen-blocker tamoxifen therapy have a 60 percent reduction in their incidence of a second, ER positive breast cancer — a common type of breast cancer which tends not to be aggressive and is responsive to estrogen-blocking therapy. But the new research shows tamoxifen increases the risk of the women developing a second and far more dangerous type of breast cancer by a stunning 440 percent….

If you are currently using this drug please contact your doctor to find out if you are at risk for more aggressive breast cancer and if you should be taking another type of drug.
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1. Soy Found To Reduce the Risk of Breast Cancer « Feminestra's Blog - December 9, 2009

[…] After a follow up of 4 years there were a documented 444 deaths and 534 cancer recurrences or breast cancer-related deaths among the 5,033 patients who where surgically treated for breast cancer. The patients who had the highest intake of soy protein had a 29 percent lower risk of death and a 32 percent lower risk of breast cancer recurrence. The researchers explained in their study that, “The inverse association was evident among women with either estrogen receptor-positive or -negative breast cancer and was present in both users and nonusers of tamoxifen.”1 […]


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